HRM-MS™ is the next generation high-content proteomics technology invented at Biognosys that enables reproducible and precise quantification of 1000s of proteins in a single instrument run with data independent acquisition (DIA). HRM-MS™ is the best proteomics method for discovery applications and highly multiplexed protein quantification.
One of the features of HRM-MS™ is that it allows retrospective analysis of target proteins, including proteins or protein isoforms that were not known or not considered relevant at the time of sample measurement. At any point in time improved or enlarged spectral libraries can be developed off-line and used for re-analysis of the HRM measurement.
The digital representation of protein signals from a sample instead of the sample itself is stored in such a Digital Biobank®. One physical measurement of a sample is therefore sufficient for any future analysis of proteins that were present in the sample.
In 2012 Biognosys has been awarded a federal grant of CHF 1.5m to further develop this technology together with the group of Ruedi Aebersold at the ETH Zurich.
Bruderer R, Bernhardt OM, Gandhi T, Miladinovic SM, Cheng LY, Messner S, et al. Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues. Mol Cell Proteomics. 2015 May;14(5):1400-10.
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